The Involvement of Norepinephrine in Behaviors Related to Psychostimulant Addiction

Title:The Involvement of Norepinephrine in Behaviors Related to Psychostimulant Addiction

Volume: 13 Issue: 3

Author(s): Magdalena Zaniewska, Małgorzata Filip and Edmund Przegalinski

Affiliation:

Keywords: Amphetamine, behavioral sensitization, cocaine, conditioned place preference, drug self-administration, intracranial self-stimulation, locomotor activity, norepinephrine.

Abstract: Although it is generally accepted that the abuse-related effects of amphetamines and cocaine result from the activation of the brain dopaminergic (DA) system, the psychostimulants also alter other neurotransmitter systems. In particular, they increase extracellular levels of norepinephrine (NE) and serotonin by inhibiting respective plasma membrane transporters and/or inducing release. The present review will discuss the preclinical findings on the effects of the NE system modulation (lesions, pharmacological and genetic approaches) on behaviors (locomotor hyperactivity, behavioral sensitization, modification of intracranial self-stimulation, conditioned place preference, drug selfadministration, extinction/reinstatement of drug seeking behavior) related to the psychostimulant addiction.

Cite this article as:

Zaniewska Magdalena, Filip Małgorzata and Przegalinski Edmund, The Involvement of Norepinephrine in Behaviors Related to Psychostimulant Addiction, Current Neuropharmacology 2015; 13 (3) . https://dx.doi.org/10.2174/1570159X13666150121225659