Abstract
A series of compounds having the pyranopyrazole pharmacophore were synthesised by the traditional method and then by an unreported rapid four-component microwave assisted method. The microwave strategy required substantially shorter reaction times as compared to the traditional method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship leading to the conclusion that the presence of certain heteroatom substituents at a 3-position of the pharmacophore may be crucial for anticancer potency.
Keywords: Anticancer, green chemistry, heterocycles, microwave assisted synthesis, pyranopyrazole.
Graphical Abstract
Current Microwave Chemistry
Title:Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents
Volume: 3 Issue: 1
Author(s): Ashok Sharma, Rajdeep Chowdhury, Subhra Dash, Badvel Pallavi and Paritosh Shukla
Affiliation:
Keywords: Anticancer, green chemistry, heterocycles, microwave assisted synthesis, pyranopyrazole.
Abstract: A series of compounds having the pyranopyrazole pharmacophore were synthesised by the traditional method and then by an unreported rapid four-component microwave assisted method. The microwave strategy required substantially shorter reaction times as compared to the traditional method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship leading to the conclusion that the presence of certain heteroatom substituents at a 3-position of the pharmacophore may be crucial for anticancer potency.
Export Options
About this article
Cite this article as:
Sharma Ashok, Chowdhury Rajdeep, Dash Subhra, Pallavi Badvel and Shukla Paritosh, Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents, Current Microwave Chemistry 2016; 3 (1) . https://dx.doi.org/10.2174/2213335602666150116233238
DOI https://dx.doi.org/10.2174/2213335602666150116233238 |
Print ISSN 2213-3356 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3364 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Entropy Model for Multiplex Drug-Target Interaction Endpoints of Drug Immunotoxicity
Current Topics in Medicinal Chemistry Machine Learning Techniques and Drug Design
Current Medicinal Chemistry Biologics for the Treatment of Juvenile Idiopathic Arthritis
Current Medicinal Chemistry Interstitial Lung Disease in Idiopathic Inflammatory Myopathy
Current Rheumatology Reviews Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection
Current Immunology Reviews (Discontinued) Synthetic and Medicinal Prospective of Structurally Modified Curcumins
Current Topics in Medicinal Chemistry The Case for Using Higher Doses of First Line Anti-Tuberculosis Drugs to Optimize Efficacy
Current Pharmaceutical Design Uncovering Drug Mechanism of Action by Proteome Wide- Identification of Drug-Binding Proteins
Medicinal Chemistry Bixin Action in the Healing Process of Rats Mouth Wounds
Current Pharmaceutical Biotechnology Synthesis and <i>In-silico</i> Identification of New Bioactive 1,3,4-oxadiazole Tagged 2,3-dihydroimidazo[1,2-a]pyridine Derivatives
Current Bioactive Compounds Molecular Imaging of Therapeutic Potential of Reporter Probes
Current Drug Targets Effect of Polarization of Ligand Charges and Estimation of MM/GBSA Binding Free Energies of Some Pyrazolo[3,4-d]pyrimidine Inhibitors of Mycobacterium Tuberculosis in View of Experimental Results
Current Enzyme Inhibition Secondary Metabolites from Cordyceps Species and Their Antitumor Activity Studies
Recent Patents on Biotechnology Patent Selections
Recent Patents on Biotechnology Non-Steroidal Targets in the Diagnosis and Treatment of Endometriosis
Current Medicinal Chemistry Adenosine and Adenosine Receptors in the Pathomechanism and Treatment of Respiratory Diseases
Current Medicinal Chemistry Strategic Paradigm Shifts in the Antimicrobial Drug Discovery Process of the 21st Century
Infectious Disorders - Drug Targets Targeting Strategies in Therapeutic Applications of Toxoplasmosis: Recent Advances in Liposomal Vaccine Delivery Systems
Current Drug Targets The Relative Transcription Index: A Gene Expression Based Metric for Prioritization of Drug Candidates
Combinatorial Chemistry & High Throughput Screening Prediction of Disease-Related Genes Based on Hybrid Features
Current Proteomics