小分子生存素抑制剂的研究进展

Title:Recent Advances on Small-Molecule Survivin Inhibitors

Volume: 22 Issue: 9

Author(s): Min Xiao and Wei Li

Affiliation:

关键词: BIRC5抑制剂，抑制细胞凋亡的蛋白，蛋白与蛋白相互作用抑制剂，小分子抗癌剂，存活素和癌症，存活素抑制剂。

摘要: Survivin, a member of the inhibitor of apoptosis proteins family, is highly expressed in most human neoplasms, but its expression is very low or undetectable in terminally differentiated normal tissues. Survivin has been shown to inhibit cancer cell apoptosis and promote cell proliferation. The overexpression of survivin closely correlates with tumor progression and drug resistance. Because of its key role in tumor formation and maintenance, survivin is considered as an ideal target for anticancer treatment. However, the development of small-molecule survivin inhibitors has been challenging due to the requirement to disrupt the protein-protein interactions. Currently only a limited number of survivin inhibitors have been developed in recent years, and most of these inhibitors reduce survivin levels by interacting with other biomolecules instead of directly interacting with survivin protein. Despite these challenges, developing potent and selective small-molecule survivin inhibitors will be important both in basic science to better understand survivin biology and in translational research to develop potentially more effective, broad-spectrum anticancer agents. In this review, the functions of survivin and its role in cancer are summarized. Recent developments, challenges, and future direction of small-molecule survivin inhibitors are also discussed in detail.

Cite this article as:

Min Xiao and Wei Li , Recent Advances on Small-Molecule Survivin Inhibitors, Current Medicinal Chemistry 2015; 22 (9) . https://dx.doi.org/10.2174/0929867322666150114102146