血小板活性在炎性肠病生理病理中的作用

Title:Platelet Activity in the Pathophysiology of Inflammatory Bowel Diseases

Volume: 16 Issue: 3

Author(s): Chunqiu Chen, Yongyu Li, Zhen Yu, Zhanju Liu, Yanhong Shi, Urszula Lewandowska and Marta Sobczak, Jakub Fichna and Martin Kreis

Affiliation:

关键词: 抗血小板药物，炎性肠病，血小板，血栓。

摘要: Platelets play a crucial role in immune responses. Impaired platelet activation may cause persistent mucosal inflammation through P-selectin, CD40-CD40L and other systems influencing granulocytes, macrophages or endothelial cells. Pharmacological regulation of platelet activation may reduce thromboembolism and limit the interaction of platelets with endothelial and inflammatory cells, in turn weakening the inflammatory responses. In this review we focus on pathophysiological activities of platelets in inflammatory bowel diseases and discuss the studies on currently available anti-platelet therapies in the treatment of gastrointestinal inflammation. Finally, we provide a prospective view to new anti-platelet agents currently under development.

Cite this article as:

Chunqiu Chen, Yongyu Li, Zhen Yu, Zhanju Liu, Yanhong Shi, Urszula Lewandowska and Marta Sobczak, Jakub Fichna and Martin Kreis , Platelet Activity in the Pathophysiology of Inflammatory Bowel Diseases, Current Drug Targets 2015; 16 (3) . https://dx.doi.org/10.2174/1389450116666150113122229