Platelet Activity in the Pathophysiology of Inflammatory Bowel Diseases

Title:Platelet Activity in the Pathophysiology of Inflammatory Bowel Diseases

Volume: 16 Issue: 3

Author(s): Chunqiu Chen, Yongyu Li, Zhen Yu, Zhanju Liu, Yanhong Shi, Urszula Lewandowska, Marta Sobczak, Jakub Fichna and Martin Kreis

Affiliation:

Keywords: Anti-platelet agents, inflammatory bowel diseases, platelets, thrombosis.

Abstract: Platelets play a crucial role in immune responses. Impaired platelet activation may cause persistent mucosal inflammation through P-selectin, CD40-CD40L and other systems influencing granulocytes, macrophages or endothelial cells. Pharmacological regulation of platelet activation may reduce thromboembolism and limit the interaction of platelets with endothelial and inflammatory cells, in turn weakening the inflammatory responses. In this review we focus on pathophysiological activities of platelets in inflammatory bowel diseases and discuss the studies on currently available anti-platelet therapies in the treatment of gastrointestinal inflammation. Finally, we provide a prospective view to new anti-platelet agents currently under development.

Cite this article as:

Chen Chunqiu, Li Yongyu, Yu Zhen, Liu Zhanju, Shi Yanhong, Lewandowska Urszula, Sobczak Marta, Fichna Jakub and Kreis Martin, Platelet Activity in the Pathophysiology of Inflammatory Bowel Diseases, Current Drug Targets 2015; 16 (3) . https://dx.doi.org/10.2174/1389450116666150113122229