Abstract
In this paper, we report a rapid and facile synthesis of a series of some dihydropyrimidinone derivatives 4(a-e) and 5(a-e) under microwave radiation. All the synthesized compounds were characterized by FTIR, 1H NMR, 13C NMR and elemental analyses. The compounds were screened for in vivo anti-inflammatory activity by the carrageenan induced rat paw edema method and in vitro anti-bacterial activity against gram positive and gram negative strains of bacteria. This pharmacological assessment data revealed that compounds 4c and 5c showed good anti-inflammatory activity. Besides, compounds 4a, 4c, 5b, 5c and 5e gave excellent results for the anti-bacterial activity evaluation against the selected strains of bacteria.
Keywords: Anti-bacterial, anti-inflammatory, chloroquinoline, dihydropyrimidinone, 1, 3, 4-oxadiazole, pyrazolone.
Graphical Abstract
Related Books
2-Deoxy-D-Glucose: Chemistry and Biology
Chiral Ionic Liquids: Applications in Chemistry and Technology
Basics of Organic Chemistry: A Textbook for Undergraduate Students
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
27
2