Hydrogen Sulfide Regulates Vascular Inflammation and its Related Signaling Pathways

Title:Hydrogen Sulfide Regulates Vascular Inflammation and its Related Signaling Pathways

Volume: 9 Issue: 2

Author(s): Shasha Feng, Junbao Du, Selena Y. Chen, Wen Yu, Chaoshu Tang and Hongfang Jin

Affiliation:

Keywords: Atherosclerosis, balloon injury, hydrogen sulfide, hypertension, inflammation, NF-κB pathway, pulmonary hypertension.

Abstract: Hydrogen sulfide (H₂S) is regarded as one of the air pollutants with a rotten egg smell. However, it is recently discovered that endogenous H₂S has important physiological and pathological functions. Cystathionine- β synthase (CBS) and cystathionine- γ lyase (CSE) play key roles in the synthesis of H₂S, and CSE is also a major H₂S-formation enzyme in the cardiovascular system. Vascular inflammation is one of the most important pathological processes in a variety of vascular diseases. The present review aimed at exploring the role of hydrogen sulfide and its signaling in vascular inflammation during vascular diseases including atherosclerosis, systemic hypertension, pulmonary hypertension (PAH), and vascular balloon injury.

Cite this article as:

Feng Shasha, Du Junbao, Chen Y. Selena, Yu Wen, Tang Chaoshu and Jin Hongfang, Hydrogen Sulfide Regulates Vascular Inflammation and its Related Signaling Pathways, Current Signal Transduction Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574362409666141201204902