Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents

Title:Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents

Volume: 15 Issue: 5

Author(s): Mingming Zhang and Dianqing Sun

Affiliation:

Keywords: Alkaloid, Anticancer, Antitumor, β -Carboline, Mechanism of action, Natural product, Structureactivity relationship.

Abstract: Cancer is a leading cause of mortality worldwide, being responsible for millions of deaths annually. Therefore, novel cancer chemotherapeutic agents are urgently needed to combat this devastating disease. β - Carboline alkaloids are an important class of natural products and medicinal molecules, which exert their anticancer activities through diverse mechanisms. In this review, we cover recent natural and synthetic β - carbolines with anticancer activity that have been reported in the literature (2010-July 2014), focusing on their chemical structures, anticancer properties, structure-activity relationships, and mechanisms of action.

Cite this article as:

Zhang Mingming and Sun Dianqing, Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (5) . https://dx.doi.org/10.2174/1871520614666141128121812