Investigating the Molecular Basis of Drug Action and Response: Chemocentric Genomics and Proteomics

Title: Investigating the Molecular Basis of Drug Action and Response: Chemocentric Genomics and Proteomics

Volume: 7 Issue: 4

Author(s): Gabriele Zybarth and Nikolai Kley

Affiliation:

Keywords: Genomics, proteomics, pharmacogenetics, pharmacogenomics, chemical proteomics, drug resistance, activitybased protein profiling, yeast three-hybrid

Abstract: The genomics and proteomics sciences have fundamentally changed the ways in which drug targets are being identified, characterized and validated. Here we review how genomics and proteomics research is improving our understanding of genetic determinants of drug susceptibility and response and, conversely, how organic small molecules mediate their pharmacological effects by modulating genome and proteome activities. We also examine the effect this improved understanding has on the drug discovery and development process.

Cite this article as:

Zybarth Gabriele and Kley Nikolai, Investigating the Molecular Basis of Drug Action and Response: Chemocentric Genomics and Proteomics, Current Drug Targets 2006; 7 (4) . https://dx.doi.org/10.2174/138945006776359430