Synthesis and Biological Evaluation of Some Novel 10H-Phenothiazines, their Sulfones and Nucleosides as Possible Antimicrobial Agents

Title:Synthesis and Biological Evaluation of Some Novel 10H-Phenothiazines, their Sulfones and Nucleosides as Possible Antimicrobial Agents

Volume: 10 Issue: 3

Author(s): Naveen Gautam, Anjali Guleria, Mukesh K. Sharma, Sudesh K. Gupta, Arun Goyal and D.C. Gautam

Affiliation:

Keywords: Antimicrobial activity, nucleosides, 10H-phenothiazines, smiles rearrangement, sulfones.

Abstract: Since the time of Ehrlich (1854-1915) the antimicrobial activity of synthetic, non-chemotherapeutic compounds like phenothiazines and methylene blue, has been known. This article reports synthesis of some new 10Hphenothiazines, their sulfones and nucleosides, which have shown antimicrobial activity to a good extent against some selected strains of fungi, Gram positive and Gram negative bacteria leading us to a possibly potent class of antimicrobial agents. Reported 10H-phenothiazines were prepared using smiles rearrangement. These synthesized 10H-phenothiazines yield sulfones on oxidation with 30% hydrogen peroxide in glacial acetic acid and form nucleosides when treated with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate (sugar). Structural assignment is done by spectral and elemental investigations.

Cite this article as:

Gautam Naveen, Guleria Anjali, Sharma K. Mukesh, Gupta K. Sudesh, Goyal Arun and Gautam D.C., Synthesis and Biological Evaluation of Some Novel 10H-Phenothiazines, their Sulfones and Nucleosides as Possible Antimicrobial Agents, Current Bioactive Compounds 2014; 10 (3) . https://dx.doi.org/10.2174/1573407210666140728174315