Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs

Title:Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs

Volume: 15 Issue: 3

Author(s): Jiao Tan, Heesun Cheong, Yoon Shin Park, Hangun Kim, Meng Zhang, Cheol Moon and Yongzhuo Huang

Affiliation:

Keywords: Biomacromolecules, cell-penetrating peptide, intranasal delivery, non-invasive delivery, percutaneous delivery, topical administration.

Abstract: Biomacromolecules play an important role in the treatment of many diseases, but their topical application has been limited by their poor cell membrane permeability. Cell-penetrating peptides (CPPs) have been investigated over the past few decades as a potential strategy to overcome this challenge. CPPs can effectively mediate the cellular uptake of poorly internalized biomacromolecules without unfavorable side effects and have therefore attracted considerable interest as a viable alternative to existing parenteral therapies involving biomacromolecules. In this review, we will highlight the application of CPPs to the non-invasive delivery of biomacromolecules, with a focus on percutaneous and nasal absorption of biomacromolecules administered using CPPs.

Cite this article as:

Tan Jiao, Cheong Heesun, Park Shin Yoon, Kim Hangun, Zhang Meng, Moon Cheol and Huang Yongzhuo, Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs, Current Pharmaceutical Biotechnology 2014; 15 (3) . https://dx.doi.org/10.2174/1389201015666140617094320