Abstract
The X-linked inhibitor of apoptosis proteins (XIAP) is thought to play a key role in the unchecked proliferation of cancer cells by interfering with the signaling cascade leading to cell death. The structure and mechanism of XIAP has been widely investigated and characterized over the past few years, to the point where this may be the best understood apoptosis protein inhibitor. As a result, XIAP is viewed as an attractive target for the treatment of cancer. To date, several research groups have reported on the discovery of small molecule inhibitors of this protein. This review focuses on the discovery and optimization of these leads.
Keywords: XIAP, small molecule inhibitor, apoptosis, BIR 2, BIR 3, Smac
Current Topics in Medicinal Chemistry
Title: Small Molecule Inhibitors of the XIAP Protein-Protein Interaction
Volume: 7 Issue: 10
Author(s): Hemaka A. Rajapakse
Affiliation:
Keywords: XIAP, small molecule inhibitor, apoptosis, BIR 2, BIR 3, Smac
Abstract: The X-linked inhibitor of apoptosis proteins (XIAP) is thought to play a key role in the unchecked proliferation of cancer cells by interfering with the signaling cascade leading to cell death. The structure and mechanism of XIAP has been widely investigated and characterized over the past few years, to the point where this may be the best understood apoptosis protein inhibitor. As a result, XIAP is viewed as an attractive target for the treatment of cancer. To date, several research groups have reported on the discovery of small molecule inhibitors of this protein. This review focuses on the discovery and optimization of these leads.
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Cite this article as:
Rajapakse A. Hemaka, Small Molecule Inhibitors of the XIAP Protein-Protein Interaction, Current Topics in Medicinal Chemistry 2007; 7 (10) . https://dx.doi.org/10.2174/156802607780906816
DOI https://dx.doi.org/10.2174/156802607780906816 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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