The Use of Interferons in Respiratory Diseases

Title:The Use of Interferons in Respiratory Diseases

Volume: 9 Issue: 5

Author(s): Ori-Michael J. Benhamou, Miriam Jacobs, Jonathan Drew, Shahar Geva, Maor Waldman and Or Kalchiem-Dekel

Affiliation:

Keywords: Asthma, idiopathic pulmonary fibrosis, influenza, interferon.

Abstract: Interferons (IFNs) are a subclass of lymphocyte-released cytokines that interfere with intracellular viral replication. These drugs are classified into three groups: IFN type 1 (IFN-α, IFN-β, and IFN-ω), IFN type 2 (IFN-γ), and IFN type 3 (IFN-λ). Despite numerous trials, IFN therapy has yet to conclusively demonstrate superiority in the treatment of various pulmonary diseases. In addition to the FDA-approved and ongoing investigational uses for IFN therapy, there is a debate regarding the appropriate dosage of these agents. A retrospective literature review is moving experts towards low-dose therapies in nearly every application of IFN therapy. It is speculated that known and unknown toxicity may limit the beneficial effects of IFN therapy.

Cite this article as:

Benhamou J. Ori-Michael, Jacobs Miriam, Drew Jonathan, Geva Shahar, Waldman Maor and Kalchiem-Dekel Or, The Use of Interferons in Respiratory Diseases, Current Respiratory Medicine Reviews 2013; 9 (5) . https://dx.doi.org/10.2174/1573398X10666140520004706