Abstract
Regenerative medicine holds much promise in assisting patients to recover from injured or lost tissues and organs through organism reconstruction. Three-dimensional (3D) biomimetic models via various approaches can be used by pharmaceutical industry for controlled drug delivery. With proper biomaterials and engineering technologies, drugs can be released in a rate-manipulated manner towards targeted regions with spatial and temporal effects. Much of the success is a result of a combination of growth factors, stem cells, biomaterials, nanotechnologies, electrospinning and 3D printing techniques mimicking in vivo angiogenesis, histogenesis and tumorigenesis processes. This interdisciplinary field on biomimetic drug delivery and regenerative medicine has already opened up a new avenue for medical progress and reformation. This article presents a comprehensive review of the 3D biomimetic models in the pertinent fields of tissue and organ manufacturing, cell-material mutual interactions, bioactive agent carrier systems and anti-cancer drug delivery methods. Particularly, the potential trends and challenges of tissue and organ manufacturing are discussed from different perspectives.
Keywords: Regenerative medicine, drug delivery, biomaterials, 3D models, nanotechnology.
Current Pharmaceutical Design
Title:Application of 3D Biomimetic Models in Drug Delivery and Regenerative Medicine
Volume: 21 Issue: 12
Author(s): Yufan Xu and Xiaohong Wang
Affiliation:
Keywords: Regenerative medicine, drug delivery, biomaterials, 3D models, nanotechnology.
Abstract: Regenerative medicine holds much promise in assisting patients to recover from injured or lost tissues and organs through organism reconstruction. Three-dimensional (3D) biomimetic models via various approaches can be used by pharmaceutical industry for controlled drug delivery. With proper biomaterials and engineering technologies, drugs can be released in a rate-manipulated manner towards targeted regions with spatial and temporal effects. Much of the success is a result of a combination of growth factors, stem cells, biomaterials, nanotechnologies, electrospinning and 3D printing techniques mimicking in vivo angiogenesis, histogenesis and tumorigenesis processes. This interdisciplinary field on biomimetic drug delivery and regenerative medicine has already opened up a new avenue for medical progress and reformation. This article presents a comprehensive review of the 3D biomimetic models in the pertinent fields of tissue and organ manufacturing, cell-material mutual interactions, bioactive agent carrier systems and anti-cancer drug delivery methods. Particularly, the potential trends and challenges of tissue and organ manufacturing are discussed from different perspectives.
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Cite this article as:
Xu Yufan and Wang Xiaohong, Application of 3D Biomimetic Models in Drug Delivery and Regenerative Medicine, Current Pharmaceutical Design 2015; 21 (12) . https://dx.doi.org/10.2174/1381612821666150115154059
DOI https://dx.doi.org/10.2174/1381612821666150115154059 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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