Abstract
This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective strategies is described remarking the scope and main features of each one.
Keywords: Antitumoral, asymmetric synthesis, catalysis, cycloaddition, metal, organocatalyst.
Graphical Abstract
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