Abstract
4EGI-1 is the prototype of a novel class of anticancer agents targeting translation. Patented drug-like analogue 1 was synthesized and examined for inhibition of translation and cytotoxicity in cancer cells. Unexpectedly, 1 was found inactive in both assays.
Keywords: Cancer, eIF4E, metastatic melanoma, mRNA translation, protein synthesis, thiazoles.
Graphical Abstract
Anti-Cancer Agents in Medicinal Chemistry
Title:Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor
Volume: 15 Issue: 10
Author(s): Christine Basmadjian, Helene Malka-Mahieu and Laurent Desaubry
Affiliation:
Keywords: Cancer, eIF4E, metastatic melanoma, mRNA translation, protein synthesis, thiazoles.
Abstract: 4EGI-1 is the prototype of a novel class of anticancer agents targeting translation. Patented drug-like analogue 1 was synthesized and examined for inhibition of translation and cytotoxicity in cancer cells. Unexpectedly, 1 was found inactive in both assays.
Export Options
About this article
Cite this article as:
Basmadjian Christine, Malka-Mahieu Helene and Desaubry Laurent, Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (10) . https://dx.doi.org/10.2174/1871520615666150602092450
DOI https://dx.doi.org/10.2174/1871520615666150602092450 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Traditional Chinese Medicine Remedy to Jury: The Pharmacological Basis for the Use of Shikonin as an Anticancer Therapy
Current Medicinal Chemistry Intracellular Delivery of Tumor Antigenic Peptides in Biodegradablepolymer Adjuvant for Enhancing Cancer Immunotherapy
Current Medicinal Chemistry Low Molecular Weight and Oligomeric Chitosans and Their Bioactivities
Current Topics in Medicinal Chemistry The Implications of Sortilin/Vps10p Domain Receptors in Neurological and Human Diseases
CNS & Neurological Disorders - Drug Targets Cell Biological Manifestations of Bisdioxopiperazines: Treatment of Human Tumor Cell Lines in Culture
Anti-Cancer Agents in Medicinal Chemistry Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer
Current Genomics Heat Shock Protein 90 Inhibitors as Broad Spectrum Anti-Infectives
Current Pharmaceutical Design Advances in Photodynamic Therapy Assisted by Electroporation
Current Drug Metabolism Finding Novel Anti-carcinomas Compounds by Targeting SFRP4 Through Molecular Modeling, Docking and Dynamic Simulation Studies
Current Computer-Aided Drug Design Antiproliferative Effects of Molecular Iodine in Cancers
Current Chemical Biology Estrogen, Immunity & Autoimmune Disease
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers
Current Cancer Drug Targets Role of Epithelial Mesenchymal Transition in Prostate Tumorigenesis
Current Pharmaceutical Design Pharmacological Interventions for the Prevention and Treatment of Kidney Injury Induced by Radiotherapy: Molecular Mechanisms and Clinical Perspectives
Current Molecular Pharmacology Cervical Cancer During Pregnancy – An Approach to Diagnosis and Management
Current Women`s Health Reviews Stereoselective Pharmacodynamics and Pharmacokinetics of Proton Pump Inhibitors
Current Drug Metabolism Cancer Electrogene Therapy with Interleukin-12
Current Gene Therapy Emerging Therapeutic Potential of Whey Proteins and Peptides
Current Pharmaceutical Design Melatonin, Immune Function and Cancer
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) The Physiological/Pathophysiological Significance of Vitamin D in Cancer, Cardiovascular Disorders and Beyond
Current Drug Metabolism