Candidate Susceptibility Genes in Alzheimers Disease Are at High Risk for Being Forgotten - They Dont Give Peace of Mind...

Title: Candidate Susceptibility Genes in Alzheimers Disease Are at High Risk for Being Forgotten - They Dont Give Peace of Mind...

Volume: 7 Issue: 3

Author(s): Andras Palotas and Janos Kalman

Affiliation:

Keywords: Allele, Alzheimer's disease, determinative gene, linkage analysis, polymorphism, risk factor, risk gene, susceptibility gene

Abstract: Alzheimers disease (AD) is a genetically complex and heterogenous disorder. In a small proportion of cases, mutations in three determinative (causal) genes are responsible for autosomal dominant early-onset forms of AD. The majority of cases, however, is sporadic, late-onset AD with unknown etiology. The pathology and clinical manifestations of these forms are influenced by multiple genetic and environmental risk factors. Over the past decades, a number of candidate genes have been identified as disease modifiers with conflicting results. This study reviews susceptibility genes that are associated with increased risk of developing AD.

Cite this article as:

Palotas Andras and Kalman Janos, Candidate Susceptibility Genes in Alzheimers Disease Are at High Risk for Being Forgotten - They Dont Give Peace of Mind..., Current Drug Metabolism 2006; 7 (3) . https://dx.doi.org/10.2174/138920006776359257