H₃PW₁₂O₄₀-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines

Title:H₃PW₁₂O₄₀-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines

Volume: 17 Issue: 6

Author(s): Samad Khaksar, Seyed Meysam Baghbanian and Nastaran Barsan

Affiliation:

Keywords: Annulation, piperidine, recyclable, tandem, Tungstophosphoric acid.

Abstract: A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using H₃PW₁₂O₄₀ as a catalyst is described. The catalyst could be easily recovered after completion of the reaction and reused without a considerable change in its activity. Furthermore, in most cases the piperidine precipitates out of solution.

Cite this article as:

Khaksar Samad, Baghbanian Meysam Seyed and Barsan Nastaran, H₃PW₁₂O₄₀-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines, Combinatorial Chemistry & High Throughput Screening 2014; 17 (6) . https://dx.doi.org/10.2174/1386207316666131229132950