Novel Approach for the Synthesis of Pyrrolo[2,1-c][1,4]Benzoxazines and Pyrrolo[1,2-a]Quinoxalines

Title:Novel Approach for the Synthesis of Pyrrolo[2,1-c][1,4]Benzoxazines and Pyrrolo[1,2-a]Quinoxalines

Volume: 17 Issue: 2

Author(s): Tayebeh Sanaeishoar, Somayeh Adibi-Sedeh and Saghar Karimian

Affiliation:

Keywords: o-aminophenols, o-phenylenediamine, p-toluene sulfonic acid, pyrrolo[1, 2-a]quinoxaline, pyrrolo[2, 1-c][1, 4]benzoxazine, β- nitrostyrenes.

Abstract: An efficient synthesis of alkyl 4,5-dihydro-4-oxo-2-phenylpyrrolo[2,1-c][1,4]benzoxazine-3-carboxylates and alkyl 4,5-dihydro-4-oxo-2-phenylpyrrolo[1,2-a]quinoxaline-3-carboxylates is described. This involves a three-component reaction between o-aminophenols or o-phenylenediamine, acetylenic esters and β-nitrostyrene derivatives using p-toluene sulfonic acid as a catalyst.

Cite this article as:

Sanaeishoar Tayebeh, Adibi-Sedeh Somayeh and Karimian Saghar, Novel Approach for the Synthesis of Pyrrolo[2,1-c][1,4]Benzoxazines and Pyrrolo[1,2-a]Quinoxalines, Combinatorial Chemistry & High Throughput Screening 2014; 17 (2) . https://dx.doi.org/10.2174/1386207316666131227150430