Protective Role of Melatonin in Liver Damage

Title:Protective Role of Melatonin in Liver Damage

Volume: 20 Issue: 30

Author(s): Cezary Chojnacki, Ewa Walecka-Kapica, Marek Romanowski, Jan Chojnacki and Grazyna Klupinska

Affiliation:

Keywords: Melatonin, liver damage, steatohepatitis, liver cirrhosis, hepatic encephalopathy.

Abstract: The liver plays a key role in the detoxification of numerous molecules which results in the formation of an excessive number of toxic reactive oxygen species. This results in oxidative damage to the hepatocytes, which when severe, compromises the function of this critical organ. A variety of antioxidants protect the liver from free radical-mediated damage, one of the best of which is melatonin. Clinical studies have confirmed the melatonin, as well as it precursor tryptophan, protect the liver from non-alcoholic liver disease and also during the surgical procedure of partial liver resection.

Cite this article as:

Chojnacki Cezary, Walecka-Kapica Ewa, Romanowski Marek, Chojnacki Jan and Klupinska Grazyna, Protective Role of Melatonin in Liver Damage, Current Pharmaceutical Design 2014; 20 (30) . https://dx.doi.org/10.2174/1381612819666131119102155