Anti-cancer Therapies in High Grade Gliomas

Title:Anti-cancer Therapies in High Grade Gliomas

Volume: 10 Issue: 3

Author(s): Cristiana Pistol Tanase, Ana-Maria Enciu, Simona Mihai, Ana Iulia Neagu, Bogdan Calenic and Maria Linda Cruceru

Affiliation:

Keywords: Antiangiogenic therapy, cancer stem cells, glioma, microRNA, personalized medicine, PI-3K.

Abstract: High grade gliomas represent one of the most aggressive and treatment-resistant types of human cancer, with only 1–2 years median survival rate for patients with grade IV glioma. The treatment of glioblastoma is a considerable therapeutic challenge; combination therapy targeting multiple pathways is becoming a fast growing area of research. This review offers an up-to-date perspective of the literature about current molecular therapy targets in high grade glioma, that include angiogenic signals, tyrosine kinase receptors, nodal signaling proteins and cancer stem cells related approaches. Simultaneous identification of proteomic signatures could provide biomarker panels for diagnostic and personalized treatment of different subsets of glioblastoma. Personalized medicine is starting to gain importance in clinical care, already having recorded a series of successes in several types of cancer; nonetheless, in brain tumors it is still at an early stage.

Cite this article as:

Tanase Pistol Cristiana, Enciu Ana-Maria, Mihai Simona, Neagu Iulia Ana, Calenic Bogdan and Cruceru Linda Maria, Anti-cancer Therapies in High Grade Gliomas, Current Proteomics 2013; 10 (3) . https://dx.doi.org/10.2174/1570164611310030007