TMEM16A/B Associated CaCC: Structural and Functional Insights

Title:TMEM16A/B Associated CaCC: Structural and Functional Insights

Volume: 21 Issue: 1

Author(s): Chunli Pang, Hongbo Yuan, Shuxi Ren, Yafei Chen, Hailong An and Yong Zhan

Affiliation:

Keywords: CaCCs, Ca²⁺-binding site, calmodulin, TMEM16A/B.

Abstract: Calcium-activated chloride channels (CaCCs) play fundamental roles in numerous physiological processes. Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date. This makes molecular investigation of CaCCs become possible. This review discusses the latest findings of TMEM16A/B associated CaCCs, the calcium and voltage dual dependence，the reorganization of Ca²⁺-binding site, the mechanisms of direct or indirect activation, the structure-functional relationship, and the possible stereoscopic structure. TMEM16A and other members of the family are associated with several kinds of cancers and other chloride channelopathies. An understanding of TMEM16 associated channel proteins will shed some light on their role in oncology and in pharmacology development.

Cite this article as:

Pang Chunli, Yuan Hongbo, Ren Shuxi, Chen Yafei, An Hailong and Zhan Yong, TMEM16A/B Associated CaCC: Structural and Functional Insights, Protein & Peptide Letters 2014; 21 (1) . https://dx.doi.org/10.2174/09298665113206660098