Penetration of Nanoparticles into Human Skin

Title:Penetration of Nanoparticles into Human Skin

Volume: 19 Issue: 35

Author(s): Xiao Wen Liang, Zhi Ping Xu, Jeffrey Grice, Andrei V. Zvyagin, Michael S. Roberts and Xin Liu

Affiliation:

Keywords: Nanoparticles, skin penetration, stratum corneum.

Abstract: Exposure of human skin to nanoparticles (NPs) is increasing with the development of nanotechnology and new applications of NPs in medicine. Safety concerns have sparked debate on the capacity of NPs to penetrate through skin and enter into the body. This article attempts to summarize the recent evidence on whether NPs penetrate human skin and the factors that may affect the penetration. Skin structure and penetration mechanisms are reviewed to provide background information. Size, shape, formulation, surface properties and application methods and their effects on skin penetration are specifically discussed. Finally, the relationship between skin penetration and nanotoxicity is reviewed to further emphasise the importance of the research in this area.

Cite this article as:

Liang Wen Xiao, Xu Ping Zhi, Grice Jeffrey, Zvyagin V. Andrei, Roberts S. Michael and Liu Xin, Penetration of Nanoparticles into Human Skin, Current Pharmaceutical Design 2013; 19 (35) . https://dx.doi.org/10.2174/1381612811319350011