Pharmacokinetics of CNT-based Drug Delivery Systems

Title:Pharmacokinetics of CNT-based Drug Delivery Systems

Volume: 14 Issue: 8

Author(s): Rui Ye, Sheng Wang, Jing Wang, Zhiqiang Luo, Qiang Peng, Xiaoxiao Cai and Yunfeng Lin

Affiliation:

Keywords: Absorption, CNT, distribution, drug release, excretion, intracellular internalization, metabolism, tumor targeting.

Abstract: Carbon nanotubes (CNT) are allotropes of carbon with a cylindrical nanostructure. They have recently aroused great interests as drug carriers, but their pharmacokinetic profiles which determine their potentials in clinical application are yet to be fully understood. Therefore, this overview attempts to outline the processes of absorption, distribution, metabolism and excretion (ADME) that govern the pharmacokinetics of CNT. In addition, the molecular mechanisms of intracellular internalization and drug release are also discussed.

Cite this article as:

Ye Rui, Wang Sheng, Wang Jing, Luo Zhiqiang, Peng Qiang, Cai Xiaoxiao and Lin Yunfeng, Pharmacokinetics of CNT-based Drug Delivery Systems, Current Drug Metabolism 2013; 14 (8) . https://dx.doi.org/10.2174/138920021131400113