Recent Development in [1,4]Benzodiazepines as Potent Anticancer Agents: A Review

Title:Recent Development in [1,4]Benzodiazepines as Potent Anticancer Agents: A Review

Volume: 14 Issue: 3

Author(s): Rupinder Kaur Gill, Shiv Om Kaushik, Jasreen Chugh, Sumit Bansal, Anamik Shah and Jitender Bariwal

Affiliation:

Keywords: Anticancer, [1, 4]Benzodiazepines, DNA intercalating agents, Pyrrolo[1, 4]benzodiazepine, Antiarrhythmic agents, 2-Azidobenzoylchloride, Histone deacetylase inhibitors, Columbic interactions.

Abstract: The [1,4]benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]benzodiazepine from CNS acting drugs to anticancer agents. During last few decades, a large number of reports have appeared in the literature highlighting the anticancer activity of [1,4]benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]benzodiazepines as anticancer agent, their mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades till date.

Cite this article as:

Gill Kaur Rupinder, Kaushik Om Shiv, Chugh Jasreen, Bansal Sumit, Shah Anamik and Bariwal Jitender, Recent Development in [1,4]Benzodiazepines as Potent Anticancer Agents: A Review, Mini-Reviews in Medicinal Chemistry 2014; 14 (3) . https://dx.doi.org/10.2174/13895575113139990081