An Update on Saccharide Arrays

Gangliang      Huang; Yingxue      Zhang; Hong      Xu

doi:10.2174/13895575113139990068

Abstract

Saccharide arrays are powerful tools to investigate the saccharide-mediated recognition events in highthroughput mode. Many methods have been used to immobilize the saccharides on support surface in the array format. The array-based technologies were widely utilized to analyze the characters of saccharide-binding lectins and antibodies, quantitatively determine saccharide-protein interactions, detect cells and pathogens, identify disease-related antisaccharide antibodies for diagnosis, and fast assess substrate specificities of glycosyltransferases. This review has mainly summarized the fabrication methods of saccharide arrays and their applications in recent years.

Keywords: Saccharide arrays, Polysaccharide arrays, Oligosaccharide arrays, Saccharide-binding lectins and antibodies, Saccharide-protein interactions, Glycosyltransferases, Fabrication, Applications.