Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

Title:Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

Volume: 20 Issue: 33

Author(s): Shuang Zhou, Fengfei Wang, Eric T. Wong, Ekokobe Fonkem, Tze-Chen Hsieh, Joseph M. Wu and Erxi Wu

Affiliation:

Keywords: Salinomycin, cancer stem cell, toxicity, drug.

Abstract: Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Therefore, salinomycin may be considered as a promising novel anti-cancer agent despite its largely unknown mechanism of action.

This review summarizes the pharmacologic effects of salinomycin and presents possible mechanisms by which salinomycin exerts its anti-tumorigenic activities. Recent advances and potential complications that might limit the utilization of salinomycin as an anti-cancer and anti-CSC agent are also presented and discussed.

Cite this article as:

Zhou Shuang, Wang Fengfei, Wong T. Eric, Fonkem Ekokobe, Hsieh Tze-Chen, Wu M. Joseph and Wu Erxi, Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities, Current Medicinal Chemistry 2013; 20 (33) . https://dx.doi.org/10.2174/15672050113109990199