Quassinoids from Brucea Javanica Seeds Inhibiting the Replication of Tobacco Mosaic Virus

Title:Quassinoids from Brucea Javanica Seeds Inhibiting the Replication of Tobacco Mosaic Virus

Volume: 9 Issue: 3

Author(s): Zheng-Kun Zhang, Ming-An Ouyang, Jia-Sui Zhan and Zu-Jian Wu

Affiliation:

Keywords: Simaroubaceae, Brucea javanica, quassinoids, inhibition, TMV, SAR.

Abstract: Active quassinoids extracted from Brucea javanica seeds were tested for their activities against Tobacco mosaic virus (TMV). Results from activity-guided assays indicated that the compounds can reduce the replication of the virus by up to 98.5% (50 µg/mL). The active quassinoids inhibit the replication of TMV genomic and subgenomic RNAs and the synthesis of TMV coat protein in vivo but did not destroy the integrality of the virus. Structure-activity relationship (SAR) analysis indicated that the positions of the furan ring, the α,β-conjugated ketone, and integrity of the A ring had significant impacts on the antiviral activity of quassinoids.

Cite this article as:

Zhang Zheng-Kun, Ouyang Ming-An, Zhan Jia-Sui and Wu Zu-Jian, Quassinoids from Brucea Javanica Seeds Inhibiting the Replication of Tobacco Mosaic Virus, Current Bioactive Compounds 2013; 9 (3) . https://dx.doi.org/10.2174/15734072113099990013