Fast and Green One-Pot Multicomponent Synthesis of a Library of Pyrrolo[1,2-c] Pyrimidines Under Microwave Irradiation

Title:Fast and Green One-Pot Multicomponent Synthesis of a Library of Pyrrolo[1,2-c] Pyrimidines Under Microwave Irradiation

Volume: 16 Issue: 10

Author(s): Emilian Georgescu, Florentina Georgescu, Constantin Draghici, Liliana Cristian, Marcel Mirel Popa and Florea Dumitrascu

Affiliation:

Keywords: 1, 3-dipolar cycloaddition, microwaves, multicomponent reaction, N-ylide, pyrrolo[1, 2-c]pyrimidine.

Abstract: A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.

Cite this article as:

Georgescu Emilian, Georgescu Florentina, Draghici Constantin, Cristian Liliana, Popa Mirel Marcel and Dumitrascu Florea, Fast and Green One-Pot Multicomponent Synthesis of a Library of Pyrrolo[1,2-c] Pyrimidines Under Microwave Irradiation, Combinatorial Chemistry & High Throughput Screening 2013; 16 (10) . https://dx.doi.org/10.2174/13862073113169990050