ENaC Modulators and Renal Disease

Title:ENaC Modulators and Renal Disease

Volume: 6

Author(s): Diego Alvarez de la Rosa, Juan F. Navarro-Gonzalez and Teresa Giraldez

Affiliation:

Keywords: Aldosterone, amiloride, epithelial sodium channel, hypertension, mineralocorticoid receptor.

Abstract: The epithelial sodium channel (ENaC) plays an essential role in transepithelial sodium reabsorption in the renal connecting tubule and collecting duct. Therefore, controlling ENaC activity is an important regulatory event in electrolyte and extracellular volume homeostasis, and thus in the control of blood pressure. Many independent signaling pathways converge on ENaC, although the most important for its physiological role is the enhancement of channel activity by the steroid hormone aldosterone. In this review, we briefly summarize current knowledge about ENaC regulation and the different chemical compounds available to directly or indirectly modify channel function. In addition, current and possible clinical uses of ENaC and aldosterone antagonists are highlighted.

Cite this article as:

Rosa Diego Alvarez de la, Navarro-Gonzalez Juan F. and Giraldez Teresa, ENaC Modulators and Renal Disease, Current Molecular Pharmacology 2013; 6 (1) . https://dx.doi.org/10.2174/1874467211306010005