Fluorinated Tropanes

Title:Fluorinated Tropanes

Volume: 13 Issue: 8

Author(s): Jeffrey S. Stehouwer

Affiliation:

Keywords: Fluorine-18, positron emission tomography, tropane, nortropane, dopamine transporter, serotonin transporter, norepinephrine transporter.

Abstract: The development of tropane-derivatives as cocaine-addiction therapeutics identified numerous compounds with affinities for the dopamine, serotonin, and norepinephrine transporters. Many of these compounds were then adapted for use as imaging radiotracers. Incorporation of fluorine into the molecule often improved the physiochemical properties of the compound and also provided a position for radiolabeling with fluorine-18. This review provides an overview of the efforts devoted to developing fluorine-18 radiolabeled tropanes for imaging use with positron emission tomography.

Cite this article as:

Stehouwer Jeffrey S., Fluorinated Tropanes, Current Topics in Medicinal Chemistry 2013; 13 (8) . https://dx.doi.org/10.2174/1568026611313080005