Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape

Title:Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape

Volume: 15 Issue: 1

Author(s): Kenneth Blum, Marcelo Febo, Rajendra D. Badgaiyan, Zsolt Demetrovics, Thomas Simpatico, Claudia Fahlke, Oscar-Berman M., Mona Li, Kristina Dushaj and Mark S. Gold

Affiliation:

Keywords: Dopamine homeostasis, genetics, reward deficiency solution system, Reward Deficiency Syndrome (RDS).

Abstract: Background: In 1990, Blum and associates provided the first confirmed genetic link between the DRD2 polymorphisms and alcoholism. This finding was based on an earlier conceptual framework, which served as a blueprint for their seminal genetic association discovery they termed “Brain Reward Cascade.” These findings were followed by a new way of understanding all addictive behaviors (substance and non-substance) termed “Reward Deficiency Syndrome” (RDS). RDS incorporates a complex multifaceted array of inheritable behaviors that are polygenic.

Objective: In this review article, we attempt to clarify these terms and provide a working model to accurately diagnose and treat these unwanted behaviors.

Method: We are hereby proposing the development of a translational model we term "Reward Deficiency Solution System™" that incorporates neurogenetic testing and meso-limbic manipulation of a "hypodopaminergic" trait/state, which provides dopamine agonistic therapy (DAT) as well as reduced "dopamine resistance," while embracing "dopamine homeostasis."

Result: The result is better recovery and relapse prevention, despite DNA antecedents, which could impact the recovery process and relapse. Understanding the commonality of mental illness will transform erroneous labeling based on symptomatology, into a genetic and anatomical etiology. WC: 184.

Cite this article as:

Blum Kenneth, Febo Marcelo, Badgaiyan D. Rajendra, Demetrovics Zsolt, Simpatico Thomas, Fahlke Claudia, M. Oscar-Berman, Li Mona, Dushaj Kristina and Gold S. Mark, Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape, Current Neuropharmacology 2017; 15 (1) . https://dx.doi.org/10.2174/1570159X13666160512150918

DOI https://dx.doi.org/10.2174/1570159X13666160512150918	Print ISSN 1570-159X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6190