Preparation of 1,4-dihydropyridine Derivatives Using Perchloric Acid Adsorbed on Magnetic Fe₃O₄ Nanoparticles Coated with Silica

Title:Preparation of 1,4-dihydropyridine Derivatives Using Perchloric Acid Adsorbed on Magnetic Fe₃O₄ Nanoparticles Coated with Silica

Volume: 9 Issue: 2

Author(s): Mohammad Reza Mohammad Shafiee, Majid Ghashang and Abbas Fazlinia

Affiliation:

Keywords: Fe₃O₄ nano-particles, Fe₃O₄@SiO₂-HClO₄, 1, 4-dihydropyridine, Hantzsch reaction, magnetically separable nano-catalyst, cinnamaldehyde.

Abstract: Perchloric acid adsorbed on magnetic Fe₃O₄ nano-particles coated with silica (Fe₃O₄@SiO₂-HClO₄) as a magnetically separable nano-catalyst was prepared and used for the preparation of 1,4-dihydropyridine derivatives via multi-component reaction of cinnamaldehyde, aromatic amines and methyl / ethyl acetoacetate in high yields. Quantitative conversion of the reactants was achieved under solvent-free conditions; recycle of the catalyst, through convenient magnetic decantation, shows non-significant loss in activity. The prepared nano-composite has been subjected for thorough characterization with X-ray diffraction (XRD) and Field Emission Scanning Electron Microscope (FE-SEM) techniques. The average particle size of nano-particles was obtained as 70 nm.

Cite this article as:

Mohammad Shafiee Mohammad Reza, Ghashang Majid and Fazlinia Abbas, Preparation of 1,4-dihydropyridine Derivatives Using Perchloric Acid Adsorbed on Magnetic Fe₃O₄ Nanoparticles Coated with Silica, Current Nanoscience 2013; 9 (2) . https://dx.doi.org/10.2174/1573413711309020006