Colesevelam: A New and Improved Bile Acid Sequestrant?

Title:Colesevelam: A New and Improved Bile Acid Sequestrant?

Volume: 19 Issue: 17

Author(s): Konstantinos Tziomalos, Asterios Karagiannis, Dimitri P. Mikhailidis and Vasilios G. Athyros

Affiliation:

Keywords: Colesevelam, statin intolerance, glycemic control, multifactorial intervention, type 2 diabetes mellitus.

Abstract: Treatment with statins represents an essential component both of primary and secondary cardiovascular prevention strategies. However, a proportion of patients cannot reach low-density lipoprotein cholesterol (LDL-C) targets with the highest tolerable dose of a potent statin or is intolerant to statins. Several treatment options are available for these patients. Colesevelam is a relatively new bile acid sequestrant that decreases serum LDL-C levels. Moreover, colesevelam improves glycemic control and seems to be well-tolerated, at least in short-term studies. Therefore, colesevelam seems to be a useful tool for the management of high-risk patients who cannot achieve LDL-C targets with monotherapy with a potent statin.

Cite this article as:

Tziomalos Konstantinos, Karagiannis Asterios, Mikhailidis Dimitri P. and Athyros Vasilios G., Colesevelam: A New and Improved Bile Acid Sequestrant?, Current Pharmaceutical Design 2013; 19 (17) . https://dx.doi.org/10.2174/1381612811319170019