Transient Receptor Potential (TRP) Cation Channels in Diabetes

Title:Transient Receptor Potential (TRP) Cation Channels in Diabetes

Volume: 13 Issue: 3

Author(s): Barbara Colsoul, Bernd Nilius and Rudi Vennekens

Affiliation:

Keywords: Ion channels, diabetes, pancreatic beta cells, insulin, transient receptor potential channels

Abstract: Transient Receptor Potential (TRP) proteins constitute a family of cation channels with very diverse permeation and gating properties. Likewise they have a very diverse role in mammalian physiology ranging from sensory nerve endings, the cardiac muscle to immune cells. Increasing evidence has implicated TRP channels in the pathology of diabetes, both on the level of insulin release from the pancreatic ß cells and in secondary conditions such as diabetic neuropathy, nephropathy and vasculopathy. In this review we summarize these recent findings, which all together indicate that TRP channels are interesting drug targets for the treatment of patients suffering from diabetes.

Cite this article as:

Colsoul Barbara, Nilius Bernd and Vennekens Rudi, Transient Receptor Potential (TRP) Cation Channels in Diabetes, Current Topics in Medicinal Chemistry 2013; 13 (3) . https://dx.doi.org/10.2174/1568026611313030004