Cytokinin Nucleosides - Natural Compounds with a Unique Spectrum of Biological Activities

Title:Cytokinin Nucleosides - Natural Compounds with a Unique Spectrum of Biological Activities

Volume: 16 Issue: 23

Author(s): Mikhail S. Drenichev, Vladimir E. Oslovsky and Sergey N. Mikhailov

Affiliation:

Keywords: Cytokinin nucleosides, Biological activity, Synthesis, N⁶, tRNA.

Abstract: Cytokinin nucleosides exhibit antitumor, antiviral, antiprotozoal, blood pressure reducing, anti-inflammatory, and antipsychotic activity. These compounds also influence platelet aggregation and exhibit some other biological activities. Cytokinins are N⁶-substituted adenines and represent an important group of phytohormones with diverse biochemical functions in plants, stimulating cell division and plant growth. The main structural feature of cytokinin nucleosides is the presence of a hydrophobic hydrocarbon moiety at the N⁶-position of adenosine. This moiety is responsible for a difference in physicochemical and biological properties as compared to adenosine. 1-N-Tuberculosinyladenosine and N⁶-tuberculosinyladenosine are specifically produced by Mycobacterium tuberculosis as components of the plasmatic membrane, thus making them attractive targets for clinical test development. Structurally related compounds were found in marine organisms. It has been shown also that tRNA contains N⁶-isoprenyladenosine and some other related compounds. This review summarizes the structural features, biological activity, and the synthesis of cytokinin nucleosides and some of their closely related derivatives such as cytokinins and terpene derivatives of adenine.

Cite this article as:

Drenichev S. Mikhail, Oslovsky E. Vladimir and Mikhailov N. Sergey, Cytokinin Nucleosides - Natural Compounds with a Unique Spectrum of Biological Activities, Current Topics in Medicinal Chemistry 2016; 16 (23) . https://dx.doi.org/10.2174/1568026616666160414123717