Cardiac Consequences of Anti-Inflammatory Drugs in Experimental Models

Title:Cardiac Consequences of Anti-Inflammatory Drugs in Experimental Models

Volume: 12 Issue: 1

Author(s): Nolwenn Merlet, David Busseuil, Eric Rheaume and Jean-Claude Tardif

Affiliation:

Keywords: Glucocorticoids, NSAIDs, biologics, heart failure, ischemia/reperfusion, cardiac hypertrophy, cardiotoxic drugs, experimental models

Abstract: Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary heart disease and valvular heart disease, it can also be caused by adverse drug reactions. Several medications have been shown to have cardiotoxic effects. Among those therapeutic agents, anti-inflammatory drugs, including exogenous glucocorticoids, nonsteroidal anti-inflammatory drugs and biologics, which are used to treat a broad range of diseases that are associated with inflammatory processes, are widely prescribed in clinical practice. In this review, we discuss insights from experimental models on the beneficial and cardiotoxic effects of anti-inflammatory drugs.

Cite this article as:

Merlet Nolwenn, Busseuil David, Rheaume Eric and Tardif Jean-Claude, Cardiac Consequences of Anti-Inflammatory Drugs in Experimental Models, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2013; 12 (1) . https://dx.doi.org/10.2174/1871523011312010005