Colchicine: An Old Wine in a New Bottle?

Title:Colchicine: An Old Wine in a New Bottle?

Volume: 12 Issue: 1

Author(s): Francois Roubille, Ekaterini Kritikou, David Busseuil, Stephanie Barrere-Lemaire and Jean-Claude Tardif

Affiliation:

Keywords: Colchicine, pericardial diseases, pericarditis, gout, tubulin, inflammation, cardiovascular diseases

Abstract: Although colchicine, a natural product, is one of the oldest drugs still currently available, its possible functions seem to be surprisingly not well-known. Beyond its present medicinal use (gout, familial Mediterranean fever, Behcet’s disease, chondrocalcinosis and other crystal arthritis), numerous other conditions have been recently proposed for the use of this drug, including pericardial diseases. However, colchicine appears as a double-edged sword, with underestimated toxicity and frequent side effects. In this review, we present the main pharmacologic features of this drug, with an emphasis on toxicity and highlight its possible applications in the cardiovascular field.

Cite this article as:

Roubille Francois, Kritikou Ekaterini, Busseuil David, Barrere-Lemaire Stephanie and Tardif Jean-Claude, Colchicine: An Old Wine in a New Bottle?, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2013; 12 (1) . https://dx.doi.org/10.2174/1871523011312010004