The Effects of Direct Renin Inhibitor, Aliskiren, on Arterial Hypertension, Chronic Kidney Disease and Cardiovascular Disease: Optimal Pharmacotherapy

Title:The Effects of Direct Renin Inhibitor, Aliskiren, on Arterial Hypertension, Chronic Kidney Disease and Cardiovascular Disease: Optimal Pharmacotherapy

Volume: 11 Issue: 1

Author(s): Yoshiyuki Morishita and Eiji Kusano

Affiliation:

Keywords: Aliskiren, angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, arterial hypertension, cardiovascular disease, chronic kidney disease, clinical trials, combination therapy, direct renin inhibitor, reni-angiotensinaldosterone system

Abstract: The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of progression of arterial hypertension, chronic kidney disease (CKD) and cardiovascular disease (CVD). Previous studies suggested that a direct renin inhibitor, aliskiren, may be effective for blood pressure lowering, renoprotection and cardiovascular protection. This review focuses on the effects of aliskiren for arterial hypertension, CKD and CVD.

Cite this article as:

Morishita Yoshiyuki and Kusano Eiji, The Effects of Direct Renin Inhibitor, Aliskiren, on Arterial Hypertension, Chronic Kidney Disease and Cardiovascular Disease: Optimal Pharmacotherapy, Cardiovascular & Hematological Agents in Medicinal Chemistry 2013; 11 (1) . https://dx.doi.org/10.2174/1871525711311010012