Expeditious Solvent-Free Synthesis of Chromene Derivatives via Three- Component Reactions of N-Nucleophiles

Mohammad      R. Hosseini-Tabatabaei; Faramarz      Rostami-Charati

doi:10.2174/138620712803901126

Abstract

Multicomponent reactions involving 4-hydroxycumarine, activated acetylenic compounds and N-nucleophiles under solvent-free conditions were investigated. The reactions could also be extended to quinoline or CH-acides. Substituted chromen could be obtained from this routine, which may have potential applications in drugs fields.

Keywords: 4-Hydroxy coumarin, acetylenic compounds, isoquinoline, one-pot reactions, solvent-free.

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Combinatorial Chemistry & High Throughput Screening

Title:Expeditious Solvent-Free Synthesis of Chromene Derivatives via Three- Component Reactions of N-Nucleophiles

Volume: 15 Issue: 10

Author(s): Mohammad R. Hosseini-Tabatabaei and Faramarz Rostami-Charati

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Keywords: 4-Hydroxy coumarin, acetylenic compounds, isoquinoline, one-pot reactions, solvent-free.

Abstract: Multicomponent reactions involving 4-hydroxycumarine, activated acetylenic compounds and N-nucleophiles under solvent-free conditions were investigated. The reactions could also be extended to quinoline or CH-acides. Substituted chromen could be obtained from this routine, which may have potential applications in drugs fields.

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R. Hosseini-Tabatabaei Mohammad and Rostami-Charati Faramarz, Expeditious Solvent-Free Synthesis of Chromene Derivatives via Three- Component Reactions of N-Nucleophiles, Combinatorial Chemistry & High Throughput Screening 2012; 15 (10) . https://dx.doi.org/10.2174/138620712803901126