Abstract
The present work is addressing the latest advances made in understanding the molecular mechanisms of vascular aging. Increased production of reactive oxygen species (ROS) is the common denominator of vascular aging, endothelial dysfunction and atherosclerosis. ROS are generated by different intracellular molecular pathways. In view of its role in determining the redox state of the cells and their responses to free radicals, mitochondrial p66Shc protein has been regarded as part of a putative transduction pathway relevant to endothelial integrity. Future efforts should translate our knowledge of the mechanisms of aging and its interaction with risk factors into the development of new therapeutic strategies to prevent age-associated cardiovascular disease.
Keywords: p66Shc, aging, endothelial dysfunction, oxidative stress
Current Vascular Pharmacology
Title:p66 Shc as the Engine of Vascular Aging
Volume: 10 Issue: 6
Author(s): Francesco Paneni and Francesco Cosentino
Affiliation:
Keywords: p66Shc, aging, endothelial dysfunction, oxidative stress
Abstract: The present work is addressing the latest advances made in understanding the molecular mechanisms of vascular aging. Increased production of reactive oxygen species (ROS) is the common denominator of vascular aging, endothelial dysfunction and atherosclerosis. ROS are generated by different intracellular molecular pathways. In view of its role in determining the redox state of the cells and their responses to free radicals, mitochondrial p66Shc protein has been regarded as part of a putative transduction pathway relevant to endothelial integrity. Future efforts should translate our knowledge of the mechanisms of aging and its interaction with risk factors into the development of new therapeutic strategies to prevent age-associated cardiovascular disease.
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Cite this article as:
Paneni Francesco and Cosentino Francesco, p66 Shc as the Engine of Vascular Aging, Current Vascular Pharmacology 2012; 10 (6) . https://dx.doi.org/10.2174/157016112803520747
DOI https://dx.doi.org/10.2174/157016112803520747 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
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