Abstract
Fibrate derivatives have a 40-year history in the management of dyslipidemia. Although this class of drugs is generally well tolerated, several safety issues have arisen from their use. In the present article we review the literature describing side effects associated with the use of fibrates except for those that are liver and muscle related. These effects are less well known but are clinically relevant.
Keywords: Fibrates, Fibric acid derivatives, Peroxisome proliferator-activated receptors (PPAR), Side effects, Adverse effects, Renal effects, Thrombosis, Gallbladder disease
Current Pharmaceutical Design
Title: Fibrate-Associated Adverse Effects Beyond Muscle and Liver Toxicity
Volume: 14 Issue: 6
Author(s): M. S. Elisaf, M. Florentin, E. N. Liberopoulos and D. P. Mikhailidis
Affiliation:
Keywords: Fibrates, Fibric acid derivatives, Peroxisome proliferator-activated receptors (PPAR), Side effects, Adverse effects, Renal effects, Thrombosis, Gallbladder disease
Abstract: Fibrate derivatives have a 40-year history in the management of dyslipidemia. Although this class of drugs is generally well tolerated, several safety issues have arisen from their use. In the present article we review the literature describing side effects associated with the use of fibrates except for those that are liver and muscle related. These effects are less well known but are clinically relevant.
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Cite this article as:
Elisaf S. M., Florentin M., Liberopoulos N. E. and Mikhailidis P. D., Fibrate-Associated Adverse Effects Beyond Muscle and Liver Toxicity, Current Pharmaceutical Design 2008; 14 (6) . https://dx.doi.org/10.2174/138161208783885362
DOI https://dx.doi.org/10.2174/138161208783885362 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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