Convection Enhanced Delivery of Macromolecules for Brain Tumors

Title:Convection Enhanced Delivery of Macromolecules for Brain Tumors

Volume: 9 Issue: 4

Author(s): Ankit I. Mehta, Bryan D. Choi, Divya Ajay, Raghu Raghavan, Martin Brady, Allan H. Friedman, Ira Pastan, Darell D. Bigner and John H. Sampson

Affiliation:

Keywords: Convection enhanced delivery, drug delivery system, glioblastoma, surrogate markers, tracers, blood brain barrier (BBB), Brain Tumors, macromolecules, surgical resection, radiation therapy

Abstract: The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.

Cite this article as:

I. Mehta Ankit, D. Choi Bryan, Ajay Divya, Raghavan Raghu, Brady Martin, H. Friedman Allan, Pastan Ira, D. Bigner Darell and H. Sampson John, Convection Enhanced Delivery of Macromolecules for Brain Tumors, Current Drug Discovery Technologies 2012; 9 (4) . https://dx.doi.org/10.2174/157016312803305951