Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells

Title:Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells

Volume: 12 Issue: 12

Author(s): Daniela Buac, Sara Schmitt, George Ventro, Fathima Rani Kona and Q. Ping Dou

Affiliation:

Keywords: Cancer therapy, Ubiquitin-Proteasome System, Apoptosis, Metal Complexes, Disulfiram, Antabuse, Proteasome inhibitors, UPS inhibitors.

Abstract: Dithiocarbamates are a class of metal-chelating compounds with various applications in medicine. They have been used for the treatment of bacterial and fungal infections, possible treatment of AIDS, and most recently cancer. Their anti-tumor effects can in part be attributed to their ability to complex tumor cellular copper, leading to binding to and inhibition of the proteasome and in turn initiating tumor cell-specific apoptosis. Current chemotherapeutic agents are highly toxic and therefore their efficacy in the eradication of tumors is greatly limited. As a result many scientists have joined the quest for novel targeted therapies in hopes of reducing toxicity while maximizing potency and proteasome inhibition has become an attractive therapy in this regard. Here we discuss the origins, mechanism, and evolution of dithiocarbamates as potent proteasome inhibitors and therefore anti-cancer agents.

Cite this article as:

Buac Daniela, Schmitt Sara, Ventro George, Rani Kona Fathima and Ping Dou Q., Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells, Mini-Reviews in Medicinal Chemistry 2012; 12 (12) . https://dx.doi.org/10.2174/138955712802762040