Inflammation in Peripheral Arterial Disease (PAD)

Salvatore      Santo Signorelli; Massimiliano      Anzaldi; Valerio      Fiore

doi:10.2174/138161212802481273

Abstract

Peripheral arterial disease (PAD) affects a large number of individuals over the age of 55 years old, and data from studies has shown a relationship between inflammation, and PAD. Many researchers have not only focused on the role played by inflammatory biomarkers and the progression of PAD, but also on the efficiency of biomarkers in monitoring medical, surgical and interventional strategies in PAD patients. In this review, Authors aim to demonstrate that biomarkers play a key role in the pathophysiology of PAD, and consequently they could be screened to highlight individuals showing these crucial pathophysiological signs. Based on a large debate about phlogosis, it is now considered to be a relevant objective in reducing the prevalence and consequences of atherosclerotic diseases such as PAD. Finally, efforts must be made towards addressing this very important objective, and consequently a greater number of studies need to be made in combatting phlogosis, especially among PAD patients.

Keywords: Peripheral arterial disease, phlogosis, biomarkers, medical therapy, inflammation, inflammatory biomarkers, atherosclerotic diseases, T-lymphocytes, C-reactive protein (CRP), Metalloproteinase (MMPS)