Perspectives on Developing Small Molecule Inhibitors Targeting HIV-1 Integrase

Title:Perspectives on Developing Small Molecule Inhibitors Targeting HIV-1 Integrase

Volume: 12 Issue: 9

Author(s): J. J. Tan, C. Liu, X. H. Sun, X. J. Cong, L. M. Hu, C. X. Wang and X. J. Liang

Affiliation:

Keywords: de novo drug design, HIV, integrase inhibitors, ligand-based drug design, pharmacophore, receptor-based drug design, virtual screening, Genetic Algorithms, DOCK

Abstract: HIV-1 integrase (IN) is a crucial enzyme in the life cycle of HIV-1 and also a validated target for developing anti-HIV inhibitors. Recent progress in drug design has significantly accelerated the development of anti-AIDS IN inhibitors. A large amount of novel inhibitors that interact specifically with IN were developed along with the expanding and application of methods to drug design. This article reviewed the anti-HIV IN inhibitors discovered by the rational drug design approaches in the recent 5-year.

Cite this article as:

J. Tan J., Liu C., H. Sun X., J. Cong X., M. Hu L., X. Wang C. and J. Liang X., Perspectives on Developing Small Molecule Inhibitors Targeting HIV-1 Integrase, Mini-Reviews in Medicinal Chemistry 2012; 12 (9) . https://dx.doi.org/10.2174/138955712800959107