TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases

Title:TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases

Volume: 13 Issue: 8

Author(s): Stella Bernardi, Daniela Milani, Bruno Fabris, Paola Secchiero and Giorgio Zauli

Affiliation:

Keywords: TRAIL, cardiovascular diseases, diabetes, Apo2 ligand, cellular apoptosis, nary artery disease, ventricular dysfunction, myocardial infarction, Therapeutic Tool

Abstract: This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.

Cite this article as:

Bernardi Stella, Milani Daniela, Fabris Bruno, Secchiero Paola and Zauli Giorgio, TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases, Current Drug Targets 2012; 13 (8) . https://dx.doi.org/10.2174/138945012802008982