Stem Cells From Umbilical Cord and Placenta for Musculoskeletal Tissue Engineering

Title:Stem Cells From Umbilical Cord and Placenta for Musculoskeletal Tissue Engineering

Volume: 7 Issue: 4

Author(s): Umile Giuseppe Longo, Mattia Loppini, Alessandra Berton, Luca La Verde, Wasim S. Khan and Vincenzo Denaro

Affiliation:

Keywords: Bone, cartilage, mesenchymal stem cells, placenta, tissue engineering, umbilical cord, cell-based therapies, regeneration, scaffolds, bone marrow

Abstract: Mesenchymal stem cells isolated from amnion/amniotic fluid, umbilical cord blood, placental tissue, umbilical cord vein and the Wharton’s Jelly are promising candidates for musculoskeletal tissue engineering of bone and cartilage tissues. The extracorporeal nature of this source avoids the ethical concerns that plague the isolation of embryonic stem cells. Moreover, the harvesting does not require the invasive and discomfort extraction procedures as well as patient risks that attend adult stem cell isolation. Current preclinical studies support the application of these cell-based therapies for the regeneration of musculoskeletal tissues. We performed a review of the literature to focus on actual knowledge and the future perspectives of the stem cells deriving from umbilical cord and placenta for musculoskeletal tissue engineering.

Cite this article as:

Giuseppe Longo Umile, Loppini Mattia, Berton Alessandra, La Verde Luca, S. Khan Wasim and Denaro Vincenzo, Stem Cells From Umbilical Cord and Placenta for Musculoskeletal Tissue Engineering, Current Stem Cell Research & Therapy 2012; 7 (4) . https://dx.doi.org/10.2174/157488812800793054