Molecular Imaging of Cancer with Radiolabeled Peptides and PET

Title:Molecular Imaging of Cancer with Radiolabeled Peptides and PET

Volume: 12 Issue: 5

Author(s): Amy L. Vavere and Raffaella Rossin

Affiliation:

Keywords: α-MSH, Bombesin, Octreotide analogs, Peptide receptors, PET, RGD, VIP, SOMATOSTATIN, NEUROENDOCRINE TUMORS, INTEGRIN, ANGIOGENESIS

Abstract: Radiolabeled peptides hold promise for diagnosis and therapy of cancer as well as for early monitoring of therapy outcomes, patient stratification, etc. This manuscript focuses on the development of peptides labeled with 18F, 64Cu, 68Ga and other positron-emitting radionuclides for PET imaging. The major techniques for radionuclide incorporation are briefly discussed. Then, examples of positronemitting peptides targeting somatostatin receptors, integrins, gastrin-releasing peptide receptors, vasointestinal peptide receptors, melanocortin 1 receptors and others are reviewed.

Cite this article as:

L. Vavere Amy and Rossin Raffaella, Molecular Imaging of Cancer with Radiolabeled Peptides and PET, Anti-Cancer Agents in Medicinal Chemistry 2012; 12 (5) . https://dx.doi.org/10.2174/187152012800617812