B Cells: Programmers of CD4 T Cell Responses

Title:B Cells: Programmers of CD4 T Cell Responses

Volume: 12 Issue: 3

Author(s): Tom A. Barr, Mohini Gray and David Gray

Affiliation:

Keywords: B cell, T cell, antigen presentation, TLR, memory, cell responses, antibody production, B cell immunobiology, CD4 T cell response, dendritic cells, protein antigens, gross abnormalities, memory cells, lymphoid organogenesis, amateur

Abstract: B cells are once again gaining prominence as important programmers of CD4 T cell responses. With widespread use of B cell depletion therapy in the clinic, proving effective in treating diseases previously considered T cellmediated, the time is right for a re-appraisal of the B cell. Though typically considered weak, Th2 driving APC, it is now clear that they are necessary for a robust and long-lived CD4 T cell response in many settings. The sphere of B cell influence extends well beyond that of simply antibody production; antigen presentation, cytokine secretion, costimulation and development of lymphoid tissue architecture are all critical aspects of B cell immunobiology, the absence of which has serious impacts for T cell priming and memory. The aim of this review is to look at non-antibody mediated B cell function and to ask how, where and when do B cells influence the CD4 T cell response?

Cite this article as:

A. Barr Tom, Gray Mohini and Gray David, B Cells: Programmers of CD4 T Cell Responses, Infectious Disorders - Drug Targets 2012; 12 (3) . https://dx.doi.org/10.2174/187152612800564446